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KMID : 0363620110320040048
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Journal of Korean Oriental Medicine
2011 Volume.32 No. 4 p.48 ~ p.67
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Inducible Mechanisms for Hepatotoxicity caused by Traditional Korean Medicines in a View of Toxicology
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Park Yeong-Chul
Park Hae-Mo
Lee Sun-Dong
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Abstract
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Objectives: There has been a lot of controversy about whether Korean traditional medicines cause drug-induced hepatotoxicity or not. However, this controversy has not been examined from a scientific approach, especially in terms of toxicology. Thus, this article for traditional Korean medicine-induced hepatotoxicity was reviewed on a basis of toxicological assessment.
Methods: Toxicological assessments were carried out in a view of reactive intermediates formation from biotransformation in animals based on cytochrome P450 activity inducing oxidative stress, and case reports in world-wide.
Results and Conclusions: Several herbal materials used for traditional Korean medicines were identified as possible agents causing drug-induced hepatotoxicity. Most of these agents seem to produce toxic reactive intermediates caused by cytochrome P450. Oxidative stress followed by cytochrome P450 activation could also be a reason for herb-induced hepatotoxicity. Plausible prevention of herb-induced hepatotoxicity was suggested.
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KEYWORD
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traditional Korean medicines, hepatotoxicity, cytochrome P450, oxidative stress, toxicology
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